The technology used in Moderna’s COVID-19 vaccine carries toxicity risks, scientists with the company said in a new paper.
“A major challenge now is how to efficiently de-risk potential toxicities associated with mRNA technology,” the scientists wrote in the paper, which was published by Nature Reviews Drug Discovery on Jan. 23.
The Moderna and Pfizer COVID-19 vaccines use modified messenger ribonucleic acid (mRNA) technology. The mRNA is delivered by lipid nanoparticles (LNP).
The toxicity risks include “lipid nanoparticle structural components, production methods, route of administration and proteins produced from complexed mRNAs,” the authors of the paper wrote.
Authors of the paper include Moderna employees Eric Jacquinet and Dimitrios Bitounis and Maximillian Rogers, who was working at Moderna when the paper was being done.
Moderna didn’t respond to a request for comment.
The mRNA vaccines have multiple known side effects, including heart inflammation and severe allergic shock. Those may stem from hypersensitivity reactions, which can be elicited by “any LNP-mRNA component” but are most likely triggered by PEGlyated lipid nanoparticles, which is “the most potentially reactogenic component,” according to the scientists.
Polyethylene glycol, or PEG, an ingredient in the Pfizer and Moderna COVID-19 vaccines, is known to cause allergic reactions. Outside scientists are divided over the mechanism behind the heart inflammation, while Pfizer has posited that the LNPs are behind the issue.
The new paper drew from prior publications and other data. The authors didn’t carry out any new experiments.
Some of the papers cited included those that have found mRNA and the spike protein delivered by Moderna’s vaccine in various parts of human beings weeks or months after vaccination, despite health officials claiming when the vaccines were rolled out that such materials would exit the body within days.
The scientists said that Moderna’s COVID-19 vaccine is “safe and effective” and hailed the development of an updated vaccine as “[demonstrating] the rapid timeline for modifications with mRNA technology in the clinic.” Due to the “transient nature of mRNA,” however, “repeat administration may be necessary,” they said.
The scientists later noted that reducing risks of toxicities with mRNA-based vaccines and drugs is necessary but “complicated.” That can be accomplished through a multipronged approach that includes advanced testing in laboratories and adjusts preclinical, animal trials to better account for “differences in human and animal physiology.”
Moderna and other companies are currently testing a number of new mRNA products, including influenza vaccines and cancer treatments.
“Thanks to the mRNA platform we built, we have an exciting pipeline, with up to 15 launches in the next five years,” Stephane Bancel, Moderna’s CEO, told investors in the company’s most recent earnings call.
The paper’s corresponding author, Mansoor Amiji of Northeastern University’s Departments of Pharmaceutical Sciences and Chemical Engineering, referred a request for comment to Mr. Bitounis, who didn’t provide any answers.
Dr. Malone Reacts
Dr. Robert Malone, who helped invent the mRNA technology, said the paper downplayed the range of risks that have been linked to the mRNA-based vaccines and may be part of a limited hangout, or a propaganda technique.
That technique, a form of misdirection, involves people offering some information to obscure or prevent the discovery of other information.
“My most generous interpretation of the overall intent of the article is that this article summarizes and represents information concerning risks and toxicities of this platform technology which Moderna wishes to have disclosed in a manner which puts the firm, its activities and the underlying platform technology in the best possible light,” Dr. Malone, who wasn’t involved with the paper, wrote in his review.
“A less generous interpretation of intent is that this article represents a subtle form of propaganda strategy commonly referred to as a limited hangout.”
That version of history explains everything.
It explains the housing crisis. It explains the energy restrictions. It explains the immigration pressure. It explains the economic stagnation. It explains why a sitting Deputy Prime Minister stood in front of graduates at an American university and asked, out loud, whether capitalist democracy still works.
None of what is happening to Canada is an accident.
The Present Is the Evidence
To understand how Canada arrived at this moment, you first have to look honestly at what is happening right now.
Across Canadian media and social media, a coordinated narrative has been building around what is being called the problem of empty bedrooms. On the surface it sounds like a housing conversation. Look closer and it is something else entirely. The pressure being applied, particularly on elderly Canadians and grandparents who have lived in their homes for decades, is to downsize. To give up their multi-bedroom homes. To turn their large homes into apartment blocks. ...
Nenshi should step down, fined, be taken to court for dereliction of duty or be removed from current leadership role due to breach of authority while in a position of power, poor memory & proved blatant deceit causing destruction & financial burden unnecessarily …. The records prove it & clarify it! His two in command should not be absolved either for not going to council when Nenshi did not! Calgarians should not be left with the costing when it should have been unnecessary! It’s called Accountability…..
